Abstract
The time of the minimum time derivative of the extracellular potentials (Φ∧) is a marker for the instant of activation when the depolarizing sodium current reaches its maximum rate of increase. This study examined the normalized averaged value of Φ∧, Φna∧, as an index of electrical activity under metabolic and hypoxic stresses. Electrical mapping was performed using a 64-electrode cage array on Langendorff perfused isolated mouse hearts at three different glucose and insulin levels during hypoxia. The lower levels of glucose and/or insulin resulted in the largest decrease of Φna∧ during hypoxia. A significant decrease in Φna∧ was a predictor of increased total activation time and propagation pattern change, and irreversible damage was predicted by a 60% decrease of Φna∧. These results supported Φna∧ as an potentially useful index of electrical activity.
Published Version
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