Experimental in- vivo animal models for asthma/ allergic asthma: importance and documented parameters- A review

Abstract

Allergies are related to foods, drugs, synthetic materials, diseases, a person's immunity, and other factors, and they cause major morbidity and socioeconomic consequences. Asthma is among the most widespread respiratory conditions in the world, affecting 6.4 million children in the United States and 350 million individuals globally; within the next 30 years, 400 million individuals are estimated to be affected. The European Union has the greatest mortality rate and the largest yearly costs at 72.2 billion euros. Allergic respiratory disorders can lead to serious, life-threatening illnesses like anaphylaxis. According to epidemiological research, these disorders and their clinical effects are currently affecting people all over the world in all age groups. As a result, people all around the world are looking for new therapies and medications with minimal or no side effects. Therefore, to conduct more research trials, scientists need an in vivo animal model and data obtained from previously published study findings. Understanding the clinical features of asthma makes it possible for us to better comprehend the pathophysiology of allergic illnesses in animals, which then enables us to apply some of this knowledge to humans. To achieve the goal of this review study, a literature search was conducted using PubMed ® (US National Library of Medicine, USA), Google Scholar, and Hilary. which is to give evidence-based recommendations for various animal models. The study covered the years 2000 through 2023. To widen the scope of this research area, information on about five animal models were gathered. Here, discusses the use of mice, rats, guinea pigs, dogs, and sheep as asthma animal models in earlier studies, and documented parameters were gathered.