Abstract
Cell types in a human experimental gingivitis model were analyzed sequentially on days 0, 4, 8, and 21 of a no oral hygiene period. The cells were characterized using enzyme and surface antigen markers. In all but two of the day 0 specimens a small inflammatory infiltrate was localized immediately beneath the junctional epithelium. These, essentially lymphocytic lesions, consisted of over 70% T‐cells as suggested by the phenotype T‐enzyme +ve/T‐cell surface antigen +ve/B‐cell surface antigen −ve/HLA‐DR −ve/B‐cell subset antigen −ve. At days 4, 8, and 21, although the size of the infiltrate increased, its essential nature did not change. At all times the majority of lymphocytes (over 70%) had the characteristic T‐cell phenotype. These results show that in the developing gingival lesion in humans a T‐cell dominated lesion occurs and persists at least for the 3 week experimental period used in the present study.
Published Version
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