Abstract
Background. Despite the wide range of studies, the development of osteoplastic material, which has not only osteoconductive but also osteoinductive properties, remains an extremely topical issue in modern medical materials science. This work is devoted to experimental evaluation of the effectiveness of synthetic osteoplastic composite material based on chitosan and hydroxyapatite.
 Aim. This study aimed to determine the effects of spongy implants based on chitosan and its composite with hydroxyapatite nanoparticles in an amount of 50 wt. % on early osteogenesis in the area of the through defect of the ileum.
 Materials and methods. The studied materials were sponge implants based on chitosan and its composite with hydroxyapatite nanoparticles in an amount of 50 wt. %. Comparison groups include those without implant placement and those with replacement with commercial Reprobone osteoplastic material. Materials were implanted into the zone of the through defect of the ileum of rabbits for a period of 28 days.
 Results. A high rate of resorption of materials based on chitosan in bone tissue and active growth of reticulofibrotic bone tissue along the edges of the defect was established, and the formation of cartilaginous islands and bone marrow was recorded in the group of chitosan implants with hydroxyapatite. The aseptic effect was observed with the use of implants made of chitosan and hydroxyapatite.
 Conclusions. The data obtained allow us to argue about the osteoconductivity of the studied materials and the prospects for further development in this direction.
Highlights
Despite the wide range of studies, the development of osteoplastic material, which has osteoconductive and osteoinductive properties, remains an extremely topical issue in modern medical materials science
This work is devoted to experimental evaluation of the effectiveness of synthetic osteoplastic composite material based on chitosan and hydroxyapatite
This study aimed to determine the effects of spongy implants based on chitosan and its composite with hydroxyapatite nanoparticles in an amount of 50 wt. % on early osteogenesis in the area of the through defect of the ileum
Summary
ЭКСПЕРИМЕНТАЛЬНАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ ХИТОЗАНОВЫХ МАТРИЦ В УСЛОВИЯХ МОДЕЛИРОВАНИЯ КОСТНОГО ДЕФЕКТА IN VIVO (предварительное сообщение). Для цитирования: Виссарионов С.В., Асадулаев М.С., Шабунин А.С., и др. Экспериментальная оценка эффективности хитозановых матриц в условиях моделирования костного дефекта in vivo (предварительное сообщение) // Ортопедия, травматология и восстановительная хирургия детского возраста. Данная работа посвящена экспериментальной оценке эффективности синтетического костнопластического композиционного материала на основе хитозана и гидроксиапатита. Цель — исследование воздействия губчатых имплантатов на основе хитозана, а также его композита с нано частицами гидроксиапатита в количестве 50 масс. В основной группе применяли губчатые имплантаты на основе хитозана и его композита с наночастицами гидроксиапатита в количестве 50 масс. Материалы имплантировали в зону сквозного дефекта подвздошной кости кроликов на 28-е сутки. Установлены высокая скорость резорбции материалов на основе хитозана в костной ткани и активн ое разрастание ретикулофиброзной костной ткани по краям дефекта, а в группе имплантатов из хитозана с гидроксиапатитом происходило образование островков хрящевой ткани и костной мозоли.
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