Abstract
Aim: To study the effects of pyrimidine derivative 4CPTP on cardiovascular system. Material and methods: Ionotropic and chronotropic effects of 4CPTP were studied using rabbit heart and frogs heart in situ preparation. Dogs blood pressure preparation was used to assess the effects of 4CPTP on blood pressure. Results: The test compound, like phenobarbitone produced dose dependent decrease in heart rate and amplitude of contractions of rabbit and frog heart and decrease in blood pressure in dogs. Conclusions: 4 CPTP possesses negative ionotropic and negative chronotropic action along with hypotensive action in animal models.
Highlights
At present, there are several techniques of new drug development- high throughput screening of potential agents, modification of the structure of existing compounds, enhancing delivery of the currently existing drugs to their site of action, serendipitous discovery and discovery of a new drug as a result of scientific enquiry into the mechanisms underlying the pathology and pathogenesis of the disease
Due to its structural resemblance to phenobarbitone, this compound has been tested for its central nervous activity in an earlier study where it showed dose dependent anti convulsant action like phenobarbitone
Effect of 4CPTP on blood pressure was studied by using adult mongrel dogs of either sex, weighing between 10-12 kg
Summary
There are several techniques of new drug development- high throughput screening of potential agents, modification of the structure of existing compounds, enhancing delivery of the currently existing drugs to their site of action, serendipitous discovery and discovery of a new drug as a result of scientific enquiry into the mechanisms underlying the pathology and pathogenesis of the disease. Structural modification of the existing compound is the main line of approach to new drug development. Due to its structural resemblance to phenobarbitone (an anti epileptic drug), this compound has been tested for its central nervous activity in an earlier study where it showed dose dependent anti convulsant action like phenobarbitone. On the contrary, this drug produced analgesic action which was contrary to hyperalgesic action produced by phenobarbitone.[3] In this study, we have tried to investigate and compare the effects of 4CPTP and phenobarbitone on cardio vascular system
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