Abstract
Lyon, Shafton and Ivy1found that subcutaneous administration of Ringer's solution prolonged the life of bilaterally nephrectomized dogs, and produced a general anasarca, frequently with ascites, hydrothorax and hydropericardium. Barry and Ivy2studied the mechanism of the edema and found that edema does not result until water with excessive sodium chloride is supplied, and that retention of urinary products per se in the presence of hypochloremia is not conducive to edema even when adequate water is supplied in the form of 4 per cent dextrose solution. The objects of the present study were: first, to observe the changes in serum proteins, and second, to determine the protein content of effusion fluids with the hope that the results might throw further light on the mechanism and type of the edema, and establish some correlation between this experimental edema and some form of clinical edema. METHODS Only large, well nourished
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