Abstract
To evaluate the feasibility of using vascularized rib and costal muscle ring to repair large circumferential defect of thoracic trachea in dog. Eighteen adult mongrel dogs were used in this study. The third rib with adjacent intercostal muscles was engineered to a ring with vascular pedicle , which replaced five or eight rings of trachea. Eleven of eighteen dogs were alive after operation , and the longest one had survived for 14 months. These dogs were active , although a slight stricture at the newly formed trachea was found. Microscopic examination showed the trachea had good blood supply , and the substitution of pleural epithelium by ciliated epithelium was observed. Circumferential tracheal replacement with vascularized rib and intercostal muscle ring is easily managed and has less complications. The results suggest that this technique might be clinically used in the future.
Published Version
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