Experimental and modeling investigation of Glibenclamide solubility in supercritical carbon dioxide

Abstract

Optimized production of micro and nanoparticles using the supercritical fluid technique requires information on the solubility of pharmaceutical materials in the supercritical fluid. In this article, Glibenclamide solubility in the SCCO2 was investigated for the first time at the temperature range 0f 308–338 K and pressure range of 12–30 MPa. Under this condition, the mole fraction of Glibenclamide was determined in the range 0.8 × 10−6 to 8.03 × 10−5. Furthermore, the six empirical models (i.e. Chrastil, Bartle et al., Mendez-Santiago and Teja (MST), Sparks et al., Bian et al., Sodeifian et al.) and PR-EoS with vdW2 mixing rule were utilized to correlate the solubility. The results confirmed that Sodeifian et al. and MST models exhibited the highest accuracy with respective Radj of 0.996 and 0.9859. Finally, the total (41.65 kJ mol-1), vaporization (65.5 kJ mol-1), and solvation. (-23.85 kJ mol-1) enthalpies were estimated by Chrastil's model and Bartle et al.