Experimental and Insilico Evaluations of Transition Metal Complexes with L-Histidine (N, N Donor) Schiff Base Ligand and Its Biological Applications in Ovarian and Melanoma Cancer Cell Lines

Abstract

Schiff base metal complexes are essential in modern coordination chemistry. It owns modern structural features and finds several uses in various fields, including pharmaceuticals, agriculture, dyeing, polymer science, food packaging, O2 detection, various biological systems, catalysis, and birth control. The Chemistry of Schiff base ligands and their metal complex increased, encompassing a wide range of organometallic compounds and bio-inorganic chemistry. Schiff bases belong to the class of organic compounds regarded as particularly significant. They have been investigated extensively in the past few years and have attracted much attention due to their appealing chemical and physical features. They are versatile and have a broader range of applications, such as anti-cancer, anti-fungal, anti-microbial, antiulcer, anti-tumor, anti-diabetic, herbicidal, anti-proliferative, and anti-inflammatory actions. The aim and objective of our research are to synthesize a series of five new Zn (II), Ni (II), Cu (II), Mn (II), and Co (III) of bis-3-(4.5-Dihydro-3 H-imidazol-4-yl)-2-[(4-methoxy-benzylidine)-amino]- propionic acid Schiff base metal complexes and to characterize those complexes by elemental analysis, UV-Visible, FT- IR, and Mass spectral studies. Bis-3-(4.5-Dihydro-3 H-imidazol-4-yl)-2-[(4-methoxy-benzylidine)-amino]-propionic acid ligand coordinates to metal ions as bidentate N and O donors. Biological studies of the synthesized Schiff base complex have also been investigated by anti-microbial, radical scavenging, docking study, anticancer analysis, and cytotoxic studies. Based on the analytical and spectral results, tetrahedral geometry has been tentatively proposed for all complexes except that of cobalt. The antioxidant studies of the Schiff base ligand and Schiff base complexes exhibit significant free radical scavenging activity against DPPH. Invitro cytotoxic activity of the Schiff complexes was evaluated against the over3 (ovarian) and melanoma cell lines (MCF14). The docking studies have been carried out using BSA protein and DNA biomolecules with synthesized metal complexes. Antimicrobial studies demonstrated the effectiveness against gram-positive and gram-negative bacteria.