Abstract
There has been conducted a study of morphofunctional ovary changes at monopolar coagulation using histological, histochemical and ultra-microscopic techniques, and there have been evaluated hemorheologic factors and state of lipid peroxidation system (LPS) in postsurgical period. It has been proved that electrocoagulation stimulates the follicle growth for a short time but damages the generative and endocrine ovary apparatus and causes evident hemodynamic changes in perifocal zone. At the same time the raise of blood viscosity and erythrocyte aggregation and LPS activation are occurring. Possessing hemorheologic and antioxidant properties ascovertin produces a protective effect on generative ovary apparatus and microcirculation in it. 48 women after laparoscopic operations on ovaries with the use of electrocoagulation have been examined prospectively. The women of the basic group took the diquertin and ascorbic acid complex prior to and after the surgery in addition to the basic therapy. There has been made an evaluation of LPS factors prior to and after the surgery, computed kymopertubation results and hormonic state in a 1 month after the surgery, frequency of pregnancy beginning. Prescription of diquertin and ascorbic acid complex under the developed procedure is pathogenetically reasonable, it allows to increase the quality of treatment after laparoscopic operations on ovaries and encourages the preservation of reproductive function of a female organism.
Highlights
There has been conducted a study of morphofunctional ovary changes at monopolar coagulation using histological, histochemical and ultra-microscopic techniques, and there have been evaluated hemorheologic factors and state of lipid peroxidation system (LPS) in postsurgical period
Possessing hemorheologic and antioxidant properties ascovertin produces a protective effect on generative ovary apparatus and microcirculation in it. 48 women after laparoscopic operations on ovaries with the use of electrocoagulation have been examined prospectively
Prescription of diquertin and ascorbic acid complex under the developed procedure is pathogenetically reasonable, it allows to increase the quality of treatment after laparoscopic operations on ovaries and encourages the preservation of reproductive function of a female organism
Summary
Особенностью современной оперативной гинекологии является широкое внедрение в практику диагностической и лечебной лапароскопии с использованием электрокоагуляции [6, 10]. В литературе широко представлены данные о влиянии монополярной коагуляции на маточные трубы, однако информации о состоянии яичников, особенно их генеративного и эндокринного аппарата, после данного метода воздействия недостаточно. До настоящего времени не разработаны эффективные методы коррекции поражения гонад вне зоны коагуляции. Вместе с тем ряд исследователей в клинической практике наблюдали нарушение менструального цикла и бесплодие у женщин, перенесших электрокоагуляцию по поводу кист яичников [5]. В НИИ фармакологии ТНЦ СО РАМН разработан препарат асковертин, включающий в себя биофлавоноид дигидрокверцетин и аскорбиновую кислоту в соотношении 1:2,5 (патент РФ ‹ 2150282). Препарат разрешен к использованию в клинической практике как общеукрепляющее средство, положительно влияющее на антиоксидантный статус организма и оказывающее капилляроукрепляющий эффект в качестве биологически активной добавки к пище «Антоксид» (РУ МЗ РФ ‹ 001284.Р.643.01.2000). Цель данной работы — экспериментально и клинически обосновать использование асковертина при монополярной коагуляции яичников
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