Experiences in supporting the structured collection of cancer nanotechnology data using caNanoLab.

Stephanie A Morris,Juli Klemm,Michal Lijowski,Sharon Gaheen,Mervi Heiskanen

doi:10.3762/bjnano.6.161

Stephanie A Morris, Juli Klemm + Show 3 more

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The cancer Nanotechnology Laboratory (caNanoLab) data portal is an online nanomaterial database that allows users to submit and retrieve information on well-characterized nanomaterials, including composition, in vitro and in vivo experimental characterizations, experimental protocols, and related publications. Initiated in 2006, caNanoLab serves as an established resource with an infrastructure supporting the structured collection of nanotechnology data to address the needs of the cancer biomedical and nanotechnology communities. The portal contains over 1,000 curated nanomaterial data records that are publicly accessible for review, comparison, and re-use, with the ultimate goal of accelerating the translation of nanotechnology-based cancer therapeutics, diagnostics, and imaging agents to the clinic. In this paper, we will discuss challenges associated with developing a nanomaterial database and recognized needs for nanotechnology data curation and sharing in the biomedical research community. We will also describe the latest version of caNanoLab, caNanoLab 2.0, which includes enhancements and new features to improve usability such as personalized views of data and enhanced search and navigation.

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The U.S annual report to the nation on the state of cancer indicates a steady decline in overall mortality rates, with increases in incidence for many cancers [1]
As we have previously reported, the caNanoLab project was initiated as a collaborative effort between the National Cancer Institute’s (NCI) Office of Cancer Nanotechnology Research and Center for Biomedical Informatics and Information Technology to address the characterization requirements for federal regulatory review of nanomaterial-based investigational new drugs, diagnostic devices, and imaging agents [11,12]. caNanoLab was originally designed to capture information about the nanomaterial sample and its composition, associated in vitro characterizations, experimental protocols, and relevant publications
The ultimate goal being to accelerate the clinical use of cancer nanomedicines by providing efficacy and safety information to support the above mentioned review process for the use of these nanomaterial in human cancer clinical trials, one of the first step to clinical use

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The U.S annual report to the nation on the state of cancer indicates a steady decline in overall mortality rates, with increases in incidence for many cancers [1]. We describe the cancer Nanotechnology Laboratory (caNanoLab) data portal, a webbased database that allows users to submit and retrieve information on highly described nanomaterials used in biomedicine. As we have previously reported, the caNanoLab project (https://cananolab.nci.nih.gov/) was initiated as a collaborative effort between the National Cancer Institute’s (NCI) Office of Cancer Nanotechnology Research and Center for Biomedical Informatics and Information Technology to address the characterization requirements for federal regulatory review of nanomaterial-based investigational new drugs, diagnostic devices, and imaging agents [11,12].

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