Abstract
Expedient phosgene-free synthesis of symmetrical diarylureas from carbamates
Highlights
Urea and its derivatives are interesting organic compounds, which have a unique chemical structure and numerous applications in a variety of fields
We report an expedient phosgene-free method for synthesis of symmetrical diaryl ureas from carbamates
When the sodium ethoxide was used in a 1:1 molar ratio the diaryl urea was not isolated after the final work-up of the reaction
Summary
Urea (carbamide) and its derivatives are interesting organic compounds, which have a unique chemical structure and numerous applications in a variety of fields. General scheme for the reported phosgene-free approaches for synthesis of 1,3-disustituted ureas. Carbamates have been used for the synthesis of different symmetrical or asymmetrical 1,3disubstituted ureas, by aminolysis reaction with primary or secondary amines in the presence of different catalysts.
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