Expanding the spectrum of sarcoma with an internal tandem duplication of BCOR: a non-pediatric nasosinusal case.

Abstract

Undifferentiated small round cells sarcomas with BCOR (BCL6 corepressor) alterations, such an internal tandem duplication within exon 15, are typically described as a pediatric group of Ewing-like small round-cell sarcomas. In contrast to this notion, we report the case of a 71-year-old woman with a nasosinusal sarcoma featuring a BCOR internal tandem duplication (ITD). To the best of our knowledge, this presence had not been previously documented in a sarcoma of the nasal and sinus cavities in an elderly patient. The identified duplication shares a similar minimal critical region as described in clear cell sarcomas of the kidney in children. This alteration, located within the PCGF1 binding domain, is believed to disrupt the activity of PRC1.12. This case underscores the need for in-depth research into the molecular biology of these rare tumors and explores potential alternative treatment options. The patient achieved remission after two cycles of doxorubicin and cyclophosphamide chemotherapy, highlighting the promise of potential therapeutic options for BCOR ITD sarcomas.