Abstract
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment which induces selective immunogenic cell death in targeted cells [1-3]. NIR-PIT utilizes an antibody–photoabsorber conjugate (APC) which is activated after tumour binding by NIR light (typically administered as laser light). A large body of research has developed around NIR-PIT, showing that it can kill many types of cancer cell by targeting unique transmembrane proteins overexpressed on the cell surface. Currently on the clinical side, a global phase III clinical trial of NIR-PIT for inoperable head and neck cancer patients is currently underway using an anti-epidermal growth factor receptor (EGFR)-antibody IR700 conjugate (https://clinicaltrials.gov/ct2/show/NCT03769506).
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