Abstract
We have developed an expandable, bioresorbable polymeric vascular stent with suitable mechanical strength and flexibility, capable of drug delivery. Poly(L-lactic acid) (MWavg 13.7kD) was dissolved with the antiinflammatory agent curcumin (diferuloyl methane) in chloroform, purified, dried, melt-extruded at 173°C and drawn (1:4–1:6) to 0.1 mm diam. Fibers were wound into 3-lobed coifs in 1,2 & 3 ply configurations and reinforced with axial fibers. Furled and balloon-expanded diameters (3 ply stent) were 2.1 and 3.4 mm. Stents were coated with di(ethylene glycol) vinyl ether (EO2V) by pulsed plasma polymerization. Stent radial compressive strength was more than adequate for vascular support. Stents (w/o curcumin) were expanded in 3.25 mm ID silicone tubes in a pig AV shunt model and perfused 1hr. Platelet adhesion was significantly reduced by EO2V (SEM, radiolabel methods). Stent fibers (w/ curcumin) were incubated with activated neutrophils and monocytes in vitro (37°C, 30 min). Curcumin significantly reduced neutrophil and monocyte adhesion, activation and superoxide production. Stents (w/o curcumin) were deployed by conventional angioplasty technique in a pig femoral artery model. Stents were patent at 1 week, but not at 2 weeks, due to an exuberant proliferative response, prompting development of the curcumin treatment.
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