Abstract
Coronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms of material processing, mechanical performance, biodegradability and manufacture techniques. Biodegradable polymers and copolymers have been widely studied as potential material candidates for bioresorbable stents. It is a great challenge to find a reasonable balance between the mechanical properties and degradation behavior of bioresorbable polymeric stents. Surface modification and drug-coating methods are generally used to improve biocompatibility and drug loading performance, which are decisive factors for the safety and efficacy of bioresorbable stents. Traditional stent manufacture techniques include etching, micro-electro discharge machining, electroforming, die-casting and laser cutting. The rapid development of 3D printing has brought continuous innovation and the wide application of biodegradable materials, which provides a novel technique for the additive manufacture of bioresorbable stents. This review aims to describe the problems regarding and the achievements of biodegradable stents from their birth to the present and discuss potential difficulties and challenges in the future.
Highlights
Vascular disease, including coronary atherosclerotic disease (CAD) and peripheral atherosclerotic disease (PAD), is a leading killer for humans in the world
This paper aims to review the comprehensive development of Bioresorbable stents (BRSs) in terms of stent material and design, mechanical properties, degradation behavior, biocompatibility and manufacture techniques
The results showed that the restenosis areas of the sheep-coated group and the pig-coated group decreased by 22.9% and 24.8% without increasing other inflammatory responses [164]
Summary
Vascular disease, including coronary atherosclerotic disease (CAD) and peripheral atherosclerotic disease (PAD), is a leading killer for humans in the world. Percutaneous coronary intervention (PCI) is a commonly used therapy for treating CAD and PAD. Balloon-expanded bare metal stents (BMSs) and drug eluting stents (DESs) are generally implanted with PCI to provide mechanical support for diseased arteries and prevent intimal hyperplasia [1]. After stent implantation, they are required to maintain good mechanical properties, biocompatibility, durability and corrosion resistance to allow for the recovery of the patient [2]. The development of stent design using materials with excellent biological and mechanical properties has become a top research topic in the biomedical and engineering fields
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