Abstract
Exoribonucleases as Modulators of Virulence in Pathogenic Bacteria
Highlights
Pathogenic bacteria are responsible for severe diseases worldwide
The present work shows that C. jejuni bacteria lacking an 3′–5′ exoribonuclease called polynucleotide phosphorylase (PNPase) is significantly less virulent than the wild-type strain (Haddad et al, 2012)
PNPase is a cold-shock protein in Escherichia coli being essential for growth at low temperatures (Zangrossi et al, 2000)
Summary
Pathogenic bacteria are responsible for severe diseases worldwide. RNA stability is a major player controlling the expression of virulence factors. The present work shows that C. jejuni bacteria lacking an 3′–5′ exoribonuclease called polynucleotide phosphorylase (PNPase) is significantly less virulent than the wild-type strain (Haddad et al, 2012). Different steps have been identified in the ability of different pathogenic bacteria to promote infection, namely motility, adherence, invasion, intracellular replication, or spreading to the neighboring cells.
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