Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity

Ekaterina A Alyamkina,Tamara E Sebeleva,Sergey S Bogachev,Nelly A Popova,Evgenia V Dolgova,Vladimir A Rogachev,Evgeniy L Gel’Fgat,Mikhail A Shurdov,Valeriy P Nikolin,Ludmila V Sakhno,Elena R Chernykh,Elena V Kiseleva,Stanislav N Zagrebelniy,Alexandr A Ostanin,Anastasia S Likhacheva,Konstantin E Orishchenko

doi:10.1016/j.cellimm.2010.01.005

Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their allostimulatory activity

Ekaterina A Alyamkina, Tamara E Sebeleva + Show 14 more

https://doi.org/10.1016/j.cellimm.2010.01.005

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Journal: Cellular immunology	Publication Date: Jan 1, 2010
Citations: 49

Affiliation: Institute of Cytology and Genetics, Gorno-Altaisk State University, Novosibirsk State University

#Allostimulatory Activity #Human Dendritic Cells + Show 8 more

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Abstract

Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli.

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