Abstract
191 Muscle damage due to exercise training has been reported to be affected by a number of factors including the type and intensity of exercise, and the quantity of exercising muscle mass. The purpose of this study was to examine the effect of exercising muscle mass on circulating creatine kinase (CK) levels. Elevated CK is an accepted clinical indicator, albeit indirect, of muscle damage. Seven volunteer spinal cord injury (SCI) patients (all males, age = 34.3±2.9 yr; wt=72.6±12.7 kg; ht=178.9±5.5 cm; time post injury of 10.1±5.7 yr) were phlebotomized before (Baseline-BA) and 48 hr after leg only (LE) and combined leg and arm maximal exercise (LA). Leg exercise was induced via electrical stimulation and took place on Regys cycle ergometer. For the combined maximal exercise condition, arm ergometry was performed on a Monark 881 concurrently with the leg cycle exercise on a separate occasion. Baseline CK levels (173.3±61.5 U/liter) were within normal laboratory range (40-280 U/liter). Statistical analysis revealed significantly (p<0.05) higher CK levels for the combined LA exercise as compared to LE exercise (481.8±299.9 U/liter vs. 209.8±110.5 U/liter, respectively). These findings contradict previous research which found no significant differences between one-arm and two-arm exercise (used to compare muscle mass differences) in CK response and suggest more research is needed to better clinically interpret the relationship between exercising muscle mass, CK response, and muscle damage. Supported by Department of Veteran's Affairs Project B2002-R
Published Version
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