Abstract
Physiology Exercise has many clear beneficial effects. Aerobic exercise elicits a coordinated metabolic response across multiple tissues. Brandao et al . unraveled the cross-talk that occurs between muscle and adipose tissue and regulation by microRNAs. In mice induced to exercise, the authors found that the energy-sensing protein kinase AMPK became activated in muscle and fat cells. A signal released into the circulation increased the expression of the type III endoribonuclease DICER in fat cells, which promoted the synthesis of microRNAs that control translation of specific messenger RNAs. Enhanced microRNA production inhibited glucose use in fat cells, which then provided substrate to support muscle in exercise training. Proc. Natl. Acad. Sci. U.S.A. 117 , 23932 (2020).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.