Abstract
Physiology Exercise has many clear beneficial effects. Aerobic exercise elicits a coordinated metabolic response across multiple tissues. Brandao et al . unraveled the cross-talk that occurs between muscle and adipose tissue and regulation by microRNAs. In mice induced to exercise, the authors found that the energy-sensing protein kinase AMPK became activated in muscle and fat cells. A signal released into the circulation increased the expression of the type III endoribonuclease DICER in fat cells, which promoted the synthesis of microRNAs that control translation of specific messenger RNAs. Enhanced microRNA production inhibited glucose use in fat cells, which then provided substrate to support muscle in exercise training. Proc. Natl. Acad. Sci. U.S.A. 117 , 23932 (2020).
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