Exercise and RNA Oxidation

Abstract

The structure and cellular location make RNA susceptible to oxidation especially by reactive oxygen species generated in the cytosol. Oxidative modifications of RNA modify both protein synthesis and cellular signaling, which may have pathophysiological consequences given that observational studies have associated RNA oxidation positively with development of neurodegenerative and cardiovascular diseases. Until now, only limited literature has investigated the relationship between exercise and RNA oxidation. However, the current evidence suggests that RNA oxidation may increase to a minor extent immediately after exercise. Hereafter, a decreased RNA oxidation level has been observed, suggesting adaptative effects of exercise on RNA oxidation. In agreement, individuals that exercise regularly have lower RNA oxidation levels than individuals who do not exercise. The changes in oxidative RNA modifications following exercise seem different and more pronounced than changes in DNA modifications. Thus, effects of exercise on RNA oxidation may be important for cellular homeostasis and contribute to understanding the protective effects of exercise against neurodegenerative and cardiovascular diseases.