Abstract
N-Acetylethionine sulfoxide contained about 90% of the radioactivity excreted in the urine of control rats injected with [ Et-1- 14C]-ethionine. N-Acetylethionine sulfoxide was identified on the basis of its chromatography on paper with the chemically synthesized compound, its deacetylation to ethionine sulfoxide, and its reduction to N-acetylethionine. N-Acetylethionine sulfoxide was also the primary excretion product of control rats injected with [ 14C]ethinine sulfoxide. Injected N-[ 14 C]- acetylethionine sulfoxide was almost quantitatively recovered in the urine. When either [ Et-1- 14C]ethionine of [ 14C]ethionine sulfoxide was injected into ethione-fed rats, about half of the radioactivity was excreted as ethione sufloxide and half as N-acetylethionine sulfoxide. N-[ 14 C] Acethylethionine sulfoxide injected into ethionine-fed rats was excreted as N-acetylethionine sulfoxide. The major pathway for the metabolism of ethionine by the rat appears to be: ethionine→ethionine sulfoxide→ N-Acetylethionine sulfoxide.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call