Abstract
ABSTRACT Sweat was collected from 5 normal male adults and 1 adult subject with cystic fibrosis of the pancreas after intravenous infusions of 4-14C-cortisol. 14C-F and 14C-E were isolated and identified in sweat (recrystallization to constant 14C/3H ratios). 14C-E accounted for more radioactivity in sweat than 14C-F (F/E ratio 0.57). In contrast, the F/E ratio in plasma at the conclusion of sweating was 5.0. Glucuronide conjugates of metabolites of 14C-F were not detected in sweat. In 4 normal adult subjects, small recoveries of intravenously administered 1,2-3H-aldosterone (3H-A) were demonstrated in thermal sweat. No conjugates of 3H-A metabolites were detected. No significant differences between normal subjects and a patient with cystic fibrosis of the pancreas were apparent in sweat 14C-F, 14C-E, or 3H-A.
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