Abstract
Actions of stizolobic acid, stizolobin acid and their derivatives were examined on the isolated spinal cord of the newborn rat. The responses were recorded from the ventral root. Stizolobic acid and its bromo-derivatives caused a depolarizing response in a dose-dependent manner. Stizolobinic acid was considerably less potent than stizolobic acid. Depolarizing responses to stizolobic acid and its bromo-derivatives were not affected by the existence of Mg 2+ and specific N-methyl- d-aspartate (NMDA) antagonists Kynurenate depressed responses to stizolobic acid. These results suggest that stizolobic acid is a new excitatory amino acid in the mammalian central neurons which binds preferably to other receptors than the NMDA-type receptor.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call