Abstract
Excess adiposity is an established risk factor for metabolic disease and visceral adipose tissue plays a major role in the low-grade inflammatory state associated with obesity. Chemokines play an important role in leukocyte trafficking and circulating chemokine levels are increased by inflammatory processes, including obesityrelated diseases. Chemokines are key factors in innate and adaptive immunity. Human adipocytes were derived from cryopreserved omental preadipocytes of subjects with a body mass index (BMI) 30 kg/m².
Highlights
Excess adiposity is an established risk factor for metabolic disease and visceral adipose tissue plays a major role in the low-grade inflammatory state associated with obesity
Human adipocytes were derived from cryopreserved omental preadipocytes of subjects with a body mass index (BMI) 30 kg/m2
Visceral adipocytes from subjects with a BMI >30 kg/m2 expressed mRNA for monocyte chemoattractant protein-1 (MCP-1/CCL2), regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), epithelial cell-derived neutrophil-activating peptide-78 (ENA-78/CXCL5), interleukin-8 (IL-8 /CXCL8), lymphotactin-β (XCL2), and fractalkine (CX3CL1)
Summary
Excess adiposity is an established risk factor for metabolic disease and visceral adipose tissue plays a major role in the low-grade inflammatory state associated with obesity. & Therapy Journal of Cell Science & Therapy Excessive Adiposity an Established Risk Factor for Metabolic Diseases Kumamoto Health Science University, Japan *Corresponding author: Yasuo Yamaguchi, Graduate school of Medical Science, Kumamoto Health Science University, Japan, Tel: +81 96-275-2111; E-mail: yamaguti@kumamoto-hsu.ac.jp
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