Abstract
Fibrocystic breast change (FBC) is extremely common and occurrs in 90% of women during their lives. The association between body composition and risk of breast cancer is well established. We hypothesized that the effect might exist during the development of FBC. Our aim was to examine the relationships of total lean mass (TLM) and percent body fat (PBF) with FBC in a general female population. In total, 8477 female subjects aged 20 years or older were enrolled in the study at the Tri-Service General Hospital in Taiwan from 2011 to 2016. Comprehensive examinations including biochemical data, measurements of body composition and breast ultrasound were performed. PBF was positively associated with the presence of FBC (OR = 1.039, 95%CI: 1.018–1.060), and TLM showed the opposite result (OR = 0.893, 95%CI: 0.861–0.926). Condition of metabolic syndrome (MetS), diabetes (DM) and fatty liver modified the association between PBF and FBC (P < 0.001, P = 0.032 and P = 0.007, respectively). Female subjects diagnosed with MetS, DM, and fatty liver had higher risk of developing FBC than control subjects (OR = 1.110, 95%CI: 1.052–1.171; OR = 1.144, 95%CI: 1.024–1.278; OR = 1.049, 95%CI: 1.019, 1.080). Those with higher PBF (for highest quartile versus lowest, OR = 2.451, 95%CI: 1.523–3.944) or lower TLM (for highest quartile versus lowest, OR = 0.279, 95%CI: 0.171–0.455) had increased risk of developing FBC. In conclusion, increased PBF and reduced TLM were likely to predict the risk of the presence of FBC in a general female population.
Highlights
These fibrocystic changes might be discovered incidentally by radiologists in women who began screening
The aim of our study was to investigate the associations between Fibrocystic breast change (FBC) with percent body fat (PBF) and total lean mass (TLM) with FBC in a large-scale general female population who had undergone health examinations in a medical center in Taiwan
PBF was positively associated with the presence of FBC with odd ratios (ORs) of 1.082, 1.045 and 1.039 (95%CI = 1.066–1.099, 1.025–1.066, 1.018–1.060) in Model 1, 2 and 3, respectively
Summary
These fibrocystic changes might be discovered incidentally by radiologists in women who began screening. In a study composed of women diagnosed with benign breast disease, females with atypical epithelial proliferation had higher risk than women over 55 years with the same diagnosis[8]. The associations between body composition and breast cancer have been examined and well established for decades[9,10]. Adipose tissue might increase the risk of breast cancer by influencing sex hormone balance, endocrine function and adipokine expression[11]. Due to the potential risk of FBC in the development of breast cancer, we were inspired to examine whether the alteration in body composition would increase the risk of FBC. The aim of our study was to investigate the associations between FBC with percent body fat (PBF) and total lean mass (TLM) with FBC in a large-scale general female population who had undergone health examinations in a medical center in Taiwan
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