Abstract
Introduction: Sickle cell disease (SCD) is a genetic disorder that can be diagnosed by early onset screening tests. In embryos and newborns with sickle cell syndrome, the anatomic development and brain circulation is less than the normal people, and brain circulation plays an important role in brain development. Objectives: The purpose of this study was to evaluate the level of IQ in children with SCD. Patients and Patients and Methods: The study was a descriptive-epidemiologic. The population of the present study was all children aged 7-14 years old with SCD in Ahvaz. The sample of this study was 50 children with SCD. They were selected from among clients referring to the hepatitis clinic of Shafa hospital in Ahvaz. About 50 healthy children were selected from the first or second-degree family members of the patients with SCD as the control group. The data was collected using Raven’s Progressive Matrices (RPM) and demographic information questionnaire. Results: The mean and standard deviation of IQ scores of the patients with SCD was 94.52 ± 14.41, and the mean and standard deviation of IQ scores of healthy subjects was 105.86 ± 11.38. The results showed a significant difference between the two groups in terms of IQ score (P<0.05). Moreover, the results showed that IQ level in patients with SCD was significant regarding their place of residence (P<0.05), however IQ level was not significant in patients with SCD regarding gender and race (P>0.05). Conclusion: The results showed that IQ in children with SCD is lower than that of the healthy subjects. Thus, the present study showed the importance of SCD on children’s IQ.
Highlights
Sickle cell disease (SCD) is a genetic disorder that can be diagnosed by early onset screening tests
Studies have shown that in embryos and infants suffering from SCD, anatomical development and brain circulation are less than the normal people; this study seeks to answer the question of whether there are differences among children with SCD and normal children regarding IQ [20,21,22]
The results showed that the mean and standard deviation of IQ scores of the patients with SCD were 94.52 ± 14.41 and the mean and standard deviation of IQ scores of healthy subjects was 105.86 ± 11.38
Summary
Sickle cell disease (SCD) is a genetic disorder that can be diagnosed by early onset screening tests. The population of the present study was all children aged 7-14 years old with SCD in Ahvaz. The sample of this study was 50 children with SCD They were selected from among clients referring to the hepatitis clinic of Shafa hospital in Ahvaz. The results showed that IQ level in patients with SCD was significant regarding their place of residence (P < 0.05), IQ level was not significant in patients with SCD regarding gender and race (P > 0.05). Conclusion: The results showed that IQ in children with SCD is lower than that of the healthy subjects. Sickle cell disease (SCD) is known as an autosomal recessive disorder occurring due to the inheritance of two HbS genes in children. The disease has a relatively low outbreak and, in some populations it has a prevalence of about 1/15 000 Patients with SCD face many complications during their life, such as anemia, sickle cell crises (pain crisis, aplastic crisis and detachment crisis), acute chest syndrome, pulmonary hypertension, Key point
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