Abstract
Abstract : Previously, we assayed several phosphotriesterase (PTE) variants with increased activity on G-type chemical nerve agents and observed increased activity on the most toxic enantiomers. The purpose of this study is to determine the feasibility of the use of ex vivo plasma assays as a means of estimating the stability of enzymes that might be candidates for in vivo treatment. Activity measurements using wild-type (WT) PTE and several of its mutants on soman and cyclosarin after incubation in human plasma indicate that WT PTE and the YT mutant of that enzyme have comparable stability in plasma.
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