Abstract
Nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) consisting of 2 Gray (Gy) total body irradiation (TBI), dog leukocyte antigen-identical marrow, and short-term postgrafting immunosuppression with cyclosporine and mycophenolate mofetil was developed in the dog model as an effective way to establish long-term, stable mixed hematopoietic chimerism. We hypothesized that Treg cells are crucial to maintaining stable mixed chimerism. All dogs in the current study were stable mixed chimeras established as described.
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