Abstract
A rapid emergence of animal-specific domains was observed in animals, contributing to specific domain combinations and functional diversification, but no similar trends were observed in other clades of eukaryotes.
Highlights
In higher multicellular eukaryotes, complex protein domain combinations contribute to various cellular functions such as regulation of intercellular or intracellular signaling and interactions
We perform a systematic survey of the eukaryotic genome sequence data currently available to elucidate how domain combinations evolved and how they are related to specific cellular functions in eukaryotes
We focus on the relationship of domain combinations and functional diversification in eukaryotes, with consideration of hierarchical classification based on their phylogenies
Summary
Complex protein domain combinations contribute to various cellular functions such as regulation of intercellular or intracellular signaling and interactions. Combinations of protein domains provide a broad spectrum for potential protein function [1,2,3,4]. Eukaryotic genome sequencing projects have revealed complicated and varied domain architectures [5]. The number of domains in a protein sequence is greater in higher eukaryotes, which have elaborate multicellular bodies. Http://genomebiology.com/2007/8/6/R121 combinations are thought to have contributed to complicated multicellular functional systems, such as cell adhesion, cell communication, and cell differentiation. We perform a systematic survey of the eukaryotic genome sequence data currently available to elucidate how domain combinations evolved and how they are related to specific cellular functions in eukaryotes
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