Abstract
Liver cancer is the most common type of cancer, it take place due to several toxic materials and drugs metabolism in our life . the surgical intervention is the main solution for treatment of liver cancer . In this study we investigate the efficiency of Vernonia amygdalina (VA) leafs phenolic extracts against hepatic tumor and renal injury induced by thioacetamide (TAA). Fourty adult males rats were used for this study and divided randomly into four equal groups (10 animals for each group) , First negative (G1) Group was given distilled water, Second positive group (G2) was IP injected with 200 mg/kg inter of TAA twice a week, While the third group (G3) was gavaged 100 mg/kg (VA), The last group (G4) taken 200 mg/kg of TAA and 100 mg/kg (VA) , After 14 weeks , the following parameters were measure ALP , ALT , AST , TB , Urea , Cr , TGF-β , A-II , Renin, ACE , ,MDA , GSH, SOD , ,TNF-α and IL-10 to evaluation the effectiveness of Vernonia amygdalina(VA) leafs extracts . the result showed that treatment with VA enhance normal liver and kidney function as well as show its effectiveness against liver cancer and renal abnormalities .
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