Evolution of Spectral Domain Optical Coherence Tomography changes in Adult Onset Vitelliform Dystrophy

Abstract

Vitelliform macular dystrophy is an autosomal dominant disorder with variable penetrance and expressivity. It was first described by Friedrich Best1 in 1905 with a complete description of various stages of this disease. Adult-onset vitelliform dystrophy, which was first described by Gass2 in 1974, differs from classic vitelliform dystrophy in that the vitelliform lesion may have a variable evolution. It manifests with bilateral mild to moderate visual loss of late onset. Electrooculogram (EOG) is normal to slightly abnormal. It is an important differential diagnosis for wet AMD where antiVEGF therapy has little or no benefit.3-5 Optical coherence tomography (OCT) is a useful tool to evaluate and document different stages of this disease. In this report, we documented OCT changes in a patient through different stages of the disease over a follow-up of 10 months.