Abstract
Evolution in action: dissemination of tet(X) into pathogenic microbiota
Highlights
Containing bacterial strains in a hospital in Sierra Leone
The need for careful monitoring of tet(X) dissemination is dictated by the fact that the enzyme encoded by the gene, a flavin-dependent monooxygenase, is capable of degrading almost all tetracyclines, including the third-generation tetracycline, tigecycline
The antibiotic is very efficient in treatment of a number of infections, including those resistant to the first- and second-generation tetracyclines (Bertrand and Dowzicky, 2012)
Summary
Containing bacterial strains in a hospital in Sierra Leone. Among 52 clinical isolates, 11 (21%) have been confirmed tet(X)-. The need for careful monitoring of tet(X) dissemination is dictated by the fact that the enzyme encoded by the gene, a flavin-dependent monooxygenase, is capable of degrading almost all tetracyclines, including the third-generation tetracycline, tigecycline Tigecycline resistance has not been tested at the time of isolation (Leski et al, 2013), the high frequency of tet(X)
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