Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms.

Milad Bastami,Ziba Nariman-Saleh-Fam,Andrea Masotti,Jalal Choupani,Yasser Mansoori,Hossein Samadi Kafil,Abdolreza Daraei,Zahra Saadatian,Bahman Yousefi,Elaheh Ouladsahebmadarek,Mahdi Mahdipour,Sepideh Zununi Vahed

doi:10.3390/ijms20205088

Abstract

Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms.

Highlights

Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms (ICD-10: C50, C51–58) that has significant contribution to cancer morbidity and mortality worldwide
We were interested in finding: which miRNA polymorphisms are hypothesized to modify the risk of female neoplasms, including breast and gynecological cancers in the literature, whether there are sufficient data to draw robust conclusions regarding the role of miRNA polymorphisms in the susceptibility to different female neoplasms, whether miRNA polymorphisms pose ethnic-specific effects in the susceptibility to female neoplasms
Titles and abstracts of the remaining 3830 records were screened and 3751 records were excluded for the following reasons: not a genetic association study (n: 1779), review articles (n: 1018), abstracts or conference papers (n: 495), studying other genes or polymorphisms (n: 179), studying other diseases (n: 138), systematic reviews or meta-analyses (n: 122), and not written in English (n: 20)

Summary

Introduction

Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms (ICD-10: C50, C51–58) that has significant contribution to cancer morbidity and mortality worldwide. Gynecological cancers (GCa) or neoplasms of the female genital organs (ICD-10: C51–C58) include cervical, ovarian, endometrial, vaginal, vulvar, and fallopian tube cancers, among which cervical cancer (CCa) and ovarian cancer (OCa) are among the 10 most common cancers in females [4]. Tumorigenesis of these cancers is an intricate process that is influenced by both environmental and genetic factors, ranging from carcinogens and reproductive factors to genetic components [5]. We were interested in finding: which miRNA polymorphisms are hypothesized to modify the risk of female neoplasms, including breast and gynecological cancers in the literature, whether there are sufficient data to draw robust conclusions regarding the role of miRNA polymorphisms in the susceptibility to different female neoplasms, whether miRNA polymorphisms pose ethnic-specific effects in the susceptibility to female neoplasms

Study Characteristics

Search Strategy

Inclusion and Exclusion Criteria

Data Extraction and Quality Assessment

Data Analysis