Evidence of the dopamine-2 receptor mediated inhibition of the hypothalamic-pituitary-adrenal system; a rodent model of hypercortisolism in chronic neuropsychiatric disorders

Balázs Thurzó,Gyula Telegdy,Zsolt Bagosi,Gyula Szabó,Eszter Kádár,Miklós Jászberényi

doi:10.15761/tbr.1000110

Abstract

Evidence of the dopamine-2 receptor mediated inhibition of the hypothalamic-pituitary-adrenal system; a rodent model of hypercortisolism in chronic neuropsychiatric disorders

Highlights

Dopaminergic neurons interconnect several brain centers and modulate a plethora of functions, the activities and disorders of three specific systems represent the most important physiologic and pathophysiologic phenomena in monoaminergic neurotransmission [1,2]
In further experiments we established that the stimulatory effect of haloperidol is dose-dependent on both the adrenocorticotropic hormone (ACTH) (Figure 2; F(3, 21)=3.2, p
The results obtained from our experiments with ether stress and selective dopaminergic antagonists refine the proposed oversimplified model of dopaminergic mediation in the control of the HPA axis [11,38,39]

Summary

Introduction

Dopaminergic neurons interconnect several brain centers and modulate a plethora of functions, the activities and disorders of three specific systems represent the most important physiologic and pathophysiologic phenomena in monoaminergic neurotransmission [1,2]. The nigrostriatal, mesocorticolimbic and hypothalamictuberoinfundibular neural networks predominantly manage inherited, instinctive, neuroendocrine programs (extrapyramidal modules, holokinetic movements, postural reflexes, and hormonal responses), but the modulation and fine-tuning provided by them have impact even on the most intricate and flexible cognitive processes [3,4] The complexity of these neural circuits is further multiplied by an arsenal of dopaminergic receptors [5,6], which explains the complex pathology of these systems (schizophrenia, attention-deficit hyperactivity disorder, Parkinson’s disease, Parkinson’s dementia, Lewy body dementia (LBD), various endocrine disorders), and the unpredictable effects and side effects (toxicity and withdrawal symptoms) of dopaminergic pharmacological agents [5,6,7,8]. The only aspect, upon which even recent publications agree, is the stimulus dependent role of various dopaminergic pathways in the transmission of the stress response [10]

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Conclusion