Evidence from a meta-analysis for the prognostic and clinicopathological importance of DKC1 in malignancies.

Abstract

Aim: We conducted a meta-analysis to evaluate the prognostic and clinicopathological relevance of DKC1 in various cancers. Methods: We searched Web of Science, Embase, PubMed, Wanfang and CNKI. Stata SE15.1 was used to calculate the hazard ratio and relative risk with 95% CIs to assess the possible correlations between DKC1 expression levels and overall and disease-free survival, as well as with clinicopathological parameters. Results: We included nine studies, with a total of 2574 patients. There was a meaningful link between elevated DKC1 and poorer disease-free (p<0.001) and overall survival (p<0.001). Also, it was linked to advanced tumor node metastasis stage (p=0.005). Conclusion: High DKC1 expression was predictive of worse prognosis and poorer clinicopathological parameters.