Abstract
The effect of bromocriptine on the antinociceptive activity of morphine has been studied in rats and mice. When administered alone, bromocriptine had no effect on the nociceptive state of the animal as reflected by the tail flick latency. However, in conjunction with morphine, bromocriptine significantly potentiated the anti-nociceptive action of morphine in both rats and mice. This potentiation was only observed at specific doses of bromocriptine and was susceptible to blockade by haloperidol. These results indicate that stimulation of at least some dopamine receptor types may modify the antinociceptive effect of morphine.
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