Abstract
Following the oral administration of 14C-bumetanide to four male volunteers, approximately 81% of the dose was excreted in the urine within 48 hrs. The remaining 14C was found in the feces and had entered the intestine via the bile. Benzene extraction of urine at pH 3.2 quantitatively extracted bumetanide from its metabolites and indicated that 63.5% of urinary 14C was unchanged bumetanide. Metabolites identified to data indicate metabolism occurring on the butyl side chain, with the primary alcohol being the major metabolite. Conjugates of these metabolites and of bometanide were also found in the urine. Only conjugates of bumetanide and its metabolites were found in the bile.
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