Abstract
THE mammalian carbonic anhydrase isozymes, CA I (or CA B) and CA II (or CA C), are single polypeptide chain molecules of about 260 amino-acid residues each1 which have been postulated to have arisen by a process of gene duplication between 120 and 300 million years ago2. The possibility that the two structural autosomal loci for these carbonic anhydrases are linked in primates has been discussed previously3 and Carter4 has recently reported genetic evidence for linkage between the CA I and CA II loci in the rodent genus Cavia. Here, we present genetic and biochemical evidence which indicates that the CA I and CA II loci are linked in the pig-tailed macaque, Macaca nemestrina.
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