Abstract
THE existence of zymographically detectable interspecific enzyme variations and the preferential loss of human chromosomes in the man–mouse as well as the man–Chinese hamster somatic cell hybrids have rendered these hybrids useful for genetic analysis of man1,2. Of these two systems, linkage studies involving the human locus for 6-phosphogluconate dehydrogenase, 6PGD, have been found feasible only in the man–Chinese hamster hybrids because the usual phenotype of human 6PGD is electrophoretically distinguishable only in this hybrid system3. This report deals with the genetic linkage relations of the human 6PGD locus in man–Chinese hamster somatic cell hybrids and provides the first evidence that the human genes for 6PGD and phosphoglucomutase1 (PGM1) are syntenic (located on the same chromosome)4.
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