Abstract
Abstract One component of injury from ionizing radiation may be the formation of new cellular antigens which are in turn immunologically rejected by the host. The following evidence seems consistent with this concept. Albino rats were immunized with bone marrow from either irradiated or nonirradiated isologous donors. When subsequently challenged with radioactive phosphorus, the irradiated-marrow recipients developed significantly more severe granulocytopenia than those immunized with normal marrow cells. These observations closely parallel more extensive ones obtained previously with radiomimetic alkylating agents. If the antigenic changes reflect modifications of DNA, then a possible mechanism for some of the cumulative and lasting effects of injury from ionizing radiation is suggested.
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