Abstract
Isolated glomeruli prepared from the renal cortex of normal and pancreatectomized diabetic rats were incubated in the presence of radioactive lysine, and the appearance of labeled lysine and hydroxylysine in non-dialyzable protein of cellular fractions was determined. Lysine incorporation and percent hydroxylysine content were higher than normal in the membrane fraction and lower than normal in the cytosol fraction in diabetes. The results are consistent with enhanced glomerular basement membrane secretion and increased hydroxylation of lysine residues in released collagen peptides in diabetes.
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