Abstract
The influenza viral protein hemagglutinin (HA) forms dense nanoscale clusters on the plasma membrane of infected cells. HA clusters mediate fusion, which is crucial to infectivity. Previous studies have shown a connection between influenza infection and phosphoinositide-related cellular processes; however, no interaction between HA and the major plasma membrane phosphoinositide PIP2 (phosphatidylinositol-(4,5)-biphosphate) has yet been shown. Super-resolution imaging in fixed cells reveals that HA and PIP2 clusters are colocalized with similar radial distribution functions. Furthermore, single particle tracking experiments in living cells indicate that PIP2 molecules have reduced mobility and increased confinement in the presence of HA clusters. This evidence suggests an underlying interaction between HA and PIP2 and merits further investigation. Understanding cellular interactions with influenza viral proteins may lead to new anti-viral therapies that are strain independent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
