Abstract
1. 1. Addition of 1·5–45 mM potassium to detrusor muscle strips in potassium-free medium produced immediate inhibition of spontaneous contractility. 2. 2. Rubidium was as effective as potassium in causing inhibition of contractility while caesium was much less effective. Lithium was ineffective. 3. 3. Inhibition of contractility by potassium was abolished by ouabain but was unaltered by drug antagonists or by a marked reduction in the external chloride concentration. 4. 4. It was concluded that the addition of potassium or of suitable substitutes, activated electrogenic sodium pumping causing hyperpolarization and inhibition of contractility.
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