Abstract
Spontaneous contractions of circular and longitudinal muscle of the ampulla and isthmus of human and rabbit Fallopian tubes were recorded isometrically. Addition of K+ to tissue in K+-free medium always caused immediate inhibition of spontaneous contractility. K+-induced inhibition was prevented by ouabain and reversed by removal of K+. It is suggested that K+ caused inhibition of contractility by activating electrogenic Na+ pumping with resultant hyperpolarization of the muscle cells.
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