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https://doi.org/10.1021/jo102147s
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Cite Journal: The Journal of Organic Chemistry |  Publication Date: Dec 21, 2010 |
 Citations: 10 |
The metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid (8) affording trianion 6 is presented and applied to the regioselective efficient construction of a series of 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives 3 that are potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins.
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