Abstract
Summary The formation of transmembrane channels by the ninth component of complement in sheep red cell membranes is the result of a series of reactions that occur in and on the membrane after the binding of this component. The energy requirements of this series of reactions vary with the species of the eighth component of complement to which the ninth component is bound. Furthermore, the results provide the first evidence that two mechanisms of channel formation exist, one that is temperature-independent and the other that has the characteristics of an enzymatic reaction with a Q10 close to 2.
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