Abstract
EVIDENCE indicates that digitalis drugs administered intravenously increase central sympathetic outflow and that this in turn results in cardiac arrhythmias1–6. The central nervous system transmitter(s) that mediates this effect is not known. According to Saito et al., noradrenaline, the primary transmitter studied so far, is not involved in the case of guinea pigs7. 5-Hydroxytryptamine (5-HT) however, may be an important chemical mediator regulating central sympathetic outflow8,9, and it is involved in the respiratory arrest induced in rats by intravenous administration of digitoxigenin10. We now report evidence that suggests that brain 5-HT is involved in digitalis-induced cardiac arrhythmias.
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