Oral Phentolamine for Treatment of Ventricular Premature Contractions.

Abstract

Meeting Abstracts1 May 1970Oral Phentolamine for Treatment of Ventricular Premature Contractions.L. Gould, M.D., F.A.C.P., R. F. Gomprecht, M.D., F.A.C.P., M. Zahir, M.D.L. Gould, M.D., F.A.C.P.Search for more papers by this author, R. F. Gomprecht, M.D., F.A.C.P.Search for more papers by this author, M. Zahir, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-779_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe beneficial effect of intravenously administered phentolamine on digitalis-induced cardiac arrhythmias has been recently demonstrated in dogs. Intravenous phentolamine has also proved valuable in reducing or abolishing digitalis- or non-digitalis-induced ventricular premature contractions in man. In addition, recent reports indicate that the drug increases myocardial contractility. These considerations prompted a clinical trial involving the oral administration of phentolamine to 20 patients with frequent ventricular premature contractions of long duration. Fifty milligrams of phentolamine were given four times a day for 2 days. If there was no effect on the contractions the dose was raised to 75 mg for 2 days... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. Gould, M.D., F.A.C.P.; R. F. Gomprecht, M.D., F.A.C.P.; M. Zahir, M.D.Affiliations: Bronx, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 779-779KeywordsArrhythmiaClinical trialsDrugsOral administration ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...