Abstract
Summary Mouse embryo cells infected with the 3049 strain of polyoma virus contain more virus-specific polyadenylated nuclear and polysomal RNA following the onset of viral DNA synthesis when compared to cells infected with a control, wild-type virus. Prior to the onset of DNA synthesis, no difference in the quantity of virus-specific, polyadenylated RNA is observed. This finding is consistent with a theory postulating the existence of a function regulating the expression of the polyoma genome following the onset of viral DNA synthesis.
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